See this article in the Las Vegas Review Journal, reporting Senate Majority Leader Harry Reid's (D-NV) dim chances of reelection next year. Reid, of course, got the Democratic leadership job when their prior senate leader, Tom Daschle (D-SD), failed to be reelected in 2004.
Much, of course, could happen to change the outcome between now and November, 2010. On the other hand, if it turns out that Reid is not reelected, much will be made of the Democrats' inability to get their senate leadership reelected.
Sadly, there seems to be little chance of the same electoral outcome for House Speaker Nancy Pelosi (D-SC). However, I'll happily settle for half a loaf.