As you know, at COTTonLINE we enjoy demography -- population trends. Comes a New Geography article about which U.S. urban areas are either net gainers or losers of residents aged 25 and older with a baccalaureate or higher degree, based on data from the Census Bureau's American Community Survey for the period 2007-2011.
As you might surmise, the regions that are the greatest net losers of adult residents with college degrees are New York City, Los Angeles, Chicago, Detroit, Philadelphia, Boston, Orlando, and San Jose. Regions showing the greatest net gains are Austin, Dallas, Phoenix, Houston, Portland, Denver, and Seattle.
You may enjoy looking at the trends for regions in which you have an interest, coded on the article's national map. The map for my state of WY shows one region gaining, the Casper area. I cannot imagine why.