Drudge Report has an item entitled:
Surge in overdoses on Skid Row caused by zombie drug Spice.
My immediate thought was of the voice-of-doom tones of a Guild Navigator proclaiming "The Spice must flow." A slang reference, of course, to the psychoactive drug melange, product of the planet Arakis, also known as Dune, from the book (by Herbert) and film of that name.