Analyses which divide the U.S. into various "nations" are always interesting; there have been several such. An article by Colin Woodard in the Tufts Magazine for alumni finds eleven different "nations" in a North America which includes all of Canada, Greenland, most of the U.S. (except southern Florida), and northern Mexico.
Based on Woodard's book, American Nations: A History of the Eleven Rival Regional Cultures of North America, the article shows how the various regions' cultures arose out of the immigrant streams which populated them, and the values those streams brought from home. Woodard shows, for example, that a resort to violence in the settling of disputes is much more likely in certain regions.
It is certain that the regions vote for different policies, parties, and priorities. Like much that is based on demography, this article is an intriguing read.