This story in The Scotsman implies strongly that Israel will attack Iran's nuclear weapon development sites within the next 18 months. If it happens, that attack is likely to precipitate all sorts of violent reactions by players on all sides, and the United States will get drawn into it, albeit reluctantly.
Presumably, the first reaction would be attacks on Israel by Hamas and Hezbollah, both clients of Iran. Another possible outcome could be an oil crisis of the sort we had during the Nixon and Carter eras. This could happen if the Islamic oil producers, furious over our likely support of Israel, decided to turn off the oil spigot.
We live in interesting times....