Wednesday, April 22, 2020

CoV and the Cytokine Storm

Writing in The Atlantic, staff writer James Hamblin, M.D., tackles the issue of why some get so sick with Covid-19 while others experience it as "like the flu" or have no symptoms whatsoever. Some of what he writes you already know.

What I found new and interesting - but definitely scary - was his description of something called a "cytokine storm" which is the patient's immune system being over-stimulated to the point where it makes the patient sicker or kills them. Not every sufferer experiences this "storm."
A cytokine is a short-lived signaling molecule that the body can release to activate inflammation in an attempt to contain and eradicate a virus. In a cytokine storm, the immune system floods the body with these molecules, essentially sounding a fire alarm that continues even after the firefighters and ambulances have arrived.

At this point, the priority for doctors shifts from hoping that a person’s immune system can fight off the virus to trying to tamp down the immune response so it doesn’t kill the person or cause permanent organ damage.

But treating any infection by impeding the immune system is always treacherous. It is never ideal to let up on a virus that can directly kill our cells. The challenge is striking a balance where neither the cytokine storm nor the infection runs rampant.
Through most of the article, Dr. Hamblin grinds few axes. With the exception of the final paragraph, which I recommend skipping, he focuses on the medical, not the political.

The lefty message is confined to his wrap-up. As you might expect, he tediously ignores economic (which is to say, human) reality. Feel free to return the favor by ignoring his socialist "commercial."